Imaging Cluster

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Atherosclerosis Imaging Research Program

 Mission

The University of Wisconsin Atherosclerosis Imaging Research Program (UW AIRP) is a core ultrasound reading and training laboratory for:

  • clinical and epidemiological research studies that use ultrasound-based research tools as surrogates for atherosclerosis and cardiovascular disease risk:
  • carotid artery intima-media thickness (carotid IMT or CIMT)
  • carotid artery plaque detection and acoustic characterization
  • brachial artery reactivity testing (BART)
  • arterial stiffness (by tonometry and/or ultrasound)
  • assessment of cardiac structure, function, and coronary blood flow (by echocardiography)
  • clinical programs that want to use carotid IMT measurements and carotid plaque detection for evaluation of subclinical atherosclerosis and assessment of cardiovascular risk

We also perform electrocardiography-based research including 12-lead ECGs, treadmill stress testing, metabolic stress testing, and Holter monitoring as well as ambulatory blood pressure measurement.

Services

  • Carotid artery ultrasonography for artery intima-media thickness (IMT), plaque detection, acoustic characterization, and stiffness
  • Brachial artery ultrasonography for reactivity and acoustic characterization
  • Carotid, femoral, and radial artery tonometry for assessment of pulse wave velocity and wave amplification and heart rate variability software for short and long term monitoring, with time and frequency domain analysis
  • Cardiac ultrasound for assessment of cardiac structure and function
  • 12-lead electrocardiography
  • Treadmill stress testing
  • Metabolic stress testing
  • Holter monitoring
  • Ambulatory blood pressure monitoring

Core lab services include sonographer and reader training, image interpretation and quantitation, data analysis, quality assurance, protocol design, and consultation.

Equipment

  • 9 Freeland Systems Access Point DICOM reading and reporting software licenses
  • 2 Freeland Systems SQL servers
  • 3 Siemens Syngo Workplace Echocardiography reading stations with Arterial Health Package software
  • 2 LifeQ software licenses for plaque and arterial wall gray scale analysis
  • 1 MIA Tools Carotid Analyzer license
  • 1 Tomtec Research Arena license
  • 2 ultrasound scanning beds, one adapted for supine bicycle stress testing echocardiography
  • 6 cardiovascular ultrasound systems (Siemens S2000, Phllips CX50, and 4 Mindray M9) equipped with cardiac and vascular transducers
  • 4 Atcor SphygmoCor arterial tonometry hardware and software packages with high fidelity tonometers
  • 1 Schiller America CS-200 treadmill/ECG system
  • 1 Schiller America AT-101 12-lead ECG system
  • 3 GE-Dinamap Pro300V2 automated blood pressure and SpO2 monitors
  • 2 GE SEER12 holter monitors
  • Contact

Lane Neuroimaging Laboratory

Mission

The HealthEmotions Research Institute seeks to use state-of-the-art scientific methods developed for the study of illness to study the relationship between emotions and health. Understanding how states of mind influence the body is part of the next great frontier in brain research. The results will have profound consequences for our understanding of the biology of emotion, our concept of health, the prevention of disease and the promotion of resilience.

Services

  • Programming guidance
  • Stimulus presentation
  • Equipment and software purchasing advice

Equipment

  • GE MR750 MRI SCANNER
  • MRI SIMULATOR
  • PSYCHOPHYSIOLOGY

Contact

 

Medical Imaging

Mission

The mission of our department is to advance human health through innovation in imaging.

Services

  • Angiography
  • CT (Computed Tomography)
  • Medical Imaging Research Support (MIRS)
  • MRI (Magnetic Resonance Imaging)
  • PET/CT (Positron Emission Tomography/Computed Tomography) Imaging
  • PET/MR (Positron Emission Tomography/Magnetic Resonance) Imaging
  • Ultrasound Imaging

Equipment

  • GE Signa Premier 3T MRI (Magnetic Resonance Imaging) Scanner
  • GE Discovery MR750 3T MRI (Magnetic Resonance Imaging) Scanner
  • GE Signa PET/MR (Positron Emission Tomography/Magnetic Resonance) Scanner
  • GE Discovery 750 CT (Computed Tomography) Scanner
  • GE Discovery D710 PET/CT (Positron Emission Tomography/Computed Tomography) Scanner
  • GE Discovery MI PET/CT (Positron Emission Tomography/Computed Tomography) Scanner
  • Supersonic Imagine Aixplorer US (Ultrasound) Scanner
  • GE Logiq E9 US (Ultrasound) Scanner
  • Siemens S2000 US (Ultrasound) Scanner
  • Siemens Sequoia US (Ultrasound) Scanner
  • Siemens Biplane Artis Zee Scanner

Contact

Medical Image Analysis Core (Radius)

Mission

Radius Medical Image Analysis is an core lab that supports the research use of medical images and image-based outcome measures in research studies by performing well-validated image analysis techniques, extending the translational research missions of Medical Physics, Radiology, and UW-Madison as a whole.

Services

  • Medical Image De-Identification and Coding
  • Cardiac MRI Analysis
  • Liver MRI Analysis
  • Tumor Response Assessment
  • Expert Reader Analysis:
  • 4D Flow MRI Analysis
  • 3D Printing

Equipment

  • CVI42 Software: for cardiac MR analysis.  Currently used by Radius staff only.
  • Mint Lesion Software:  for tumor response assessments.  Used by Radius staff only.
  • Mimics Innovation Suite-Clinical:  FDA cleared software used to generate STL files for 3D Printing.  Used by Radius staff only.
  • Formlabs Form 3 LFS Printer: Low Force Stereolithography printer, currently used by Radius staff only

Contact

Medical Imaging Research Support - Image Analysis (MIRS)

Mission

Department of Radiology Medical Imaging Research Support (MIRS) provides assistance to UW research teams interested in using medical imaging as an outcome measure. Services include imaging-specific advice with respect to protocol development, imaging manual creation, regulatory requirements, nursing and study coordination, budget, and the use of well-validated image analysis available through the Radius medical image analysis lab. Services are closely integrated with the Wisconsin Institute for Medical Research (WIMR) Imaging Services Center and involve the research program managers for each imaging modality to ensure that imaging procedures are planned in accordance with the requirements, policies, and procedures of the WIMR Imaging Services Center. A major component of MIRS operations involves close coordination with the UW Carbone Cancer Center Imaging Core to support the multiple ongoing oncologic studies that make use of imaging.

Services

Technical Consultation

  • Subspecialty trained radiologists
  • Imaging modality MD and PhD experts:
  • MRI
  • Ultrasound
  • CT
  • Fluoroscopy
  • PET

Imaging Procedures

  • Tracking Recruitment
  • Scheduling
  • Ongoing Imaging Protocol QC
  • Data Storage
  • Study Coordinators
  • Nursing
  • Quality and Compliance

   Protocol Development

  • Regulatory Support
  • Budgeting
  • Modality Expertise
  • Imaging Manual Creation

   Image Analysis (Radius)

  • 3D Printing
  • Body Composition Analysis
  • Cardiac Structure/Function
  • Expert Reader Support
  • Image De-identification and Coding Go to Research Image Requests
  • Image Upload to Sponsors
  • Incidental Findings Overreads
  • Quantitative Liver Analysis
  • Tumor Response Assessment

Equipment

  • Please add any equipment as applicable

Contact

Optical Imaging Core ֍

Mission

The University of Wisconsin Optical Imaging Core offers investigators and biotech partners training and accessibility to advanced imaging technology.

֍ This core facility utilizes iLab, an online management tool that allows researchers to request services, schedule equipment and manage billing with UW shared resources.

Services
The OIC offers imaging services on six microscopy systems

Equipment

  • Leica SP8 3X STED Super-Resolution Microscope
  • Nikon A1RS Confocal Microscope
  • Mizar Tilt Light Sheet Microscope
  • Nikon Spinning Disk Confocal Microscope
  • Nikon Multiphoton/Confocal Microscope
  • 3i Lattice Light Sheet Microscope

Contact

School of Medicine and Public Health Electron Microscope Facility

Mission

It is the mission of the University of Wisconsin School of Medicine and Public Health Electron Microcopy Core Facility to provide exceptional scientific research and service to users from within the university system and around the nation. We are a full-service facility that delivers high quality and skilled sample preparation and electron imaging services to campus users and community partners. Our work supports research grants and programs that are vital to the advancement of the university’s biological, clinical and chemical research.

Services

TEM sample preparation

  • Room temperature epoxy sample embedding
  • Ultrathin sample sectioning
  • Macromolecule, viral, and bacteria sample imaging (negative stain)
  • Methyl cellulose/Uranyl Oxalate positive staining imaging for macromolecules
  • Light level sectioning ( for histological or PPD & HRP-DAB staining)
  • Serial Block Face SEM sample preparation

Transmission Electron Imaging

  • TEM microscope rental
  • Assisted microscope operation and sample analysis
  • Serial Block Face SEM tomography imaging

Equipment

  • FEI Tecnai 12 120kV TEM w/ AMT BioSprint12 digital camera
  • Hitachi H-7600 120kV TEM w/ AMT side and Hamamatsu bottom mount cameras
  • FEI CM120 120kV TEM w/ AMT BioSprint12 digital camera
  • ZEISS Gemini and Gatan 3View serial block face SEM

Contact

Small Animal Imaging & Radiotherapy Facility (SAIRF) ֍

Mission

The SAIRF is dedicated to providing innovative, state-of-the-art, affordable, noninvasive, high-resolution, in-vivo and ex-vivo imaging and radiotherapy support to UWCCC investigators, University of Wisconsin researchers, and industry.

֍ This core facility utilizes iLab, an online management tool that allows researchers to request services, schedule equipment and manage billing with UW shared resources.

Services

  • Imaging Study Consultation
  • Animal Housing
  • Contrast Agent Development
  • Image Analysis Training
  • Tissue Collection and Biodistribution
  • Animal Injections/Administration & Blood Sampling
  • Complete Blood Count (CBC) Analysis
  • Blood Chemistry Analysis
  • micro Positron Emission Tomography (uPET)
  • micro-Single Photon Emission Computed Tomography (uSPECT)
  • micro Computed Tomography (uCT)
  • Ultrasound (US)/Photoacoustic (PA) Imaging
  • Optical (Fluorescence & Bioluminescence Imaging)
  • micro-Magnetic Resonance Imaging (uMRI)
  • Animal and Cell Irradiation

Equipment

  • micro-Positron Emission Tomography(uPET)/Computed Tomography(uCT)
  • micro-Single Photon Emission Computed Tomography (uSPECT))/Computed Tomography (uCT)
  • micro-Computed Tomography (uCT)
  • Fluoroscopy
  • Gamma Counter
  • Bioluminescence & Fluorescence In Vivo Imaging System (IVIS)
  • Near-infrared (NIR) Imaging
  • micro-Magnetic Resonance Imaging (uMRI)
  • Photoacoustic (PA) Imaging
  • Ultrasound (US) Imaging
  • Photoacoustic/Ultrasound (PA/US)
  • Hematology Complete Blood Count (CBC) Analyzer
  • Hematology Chem Analyzer
  • Radioactive Rodent Housing
  • Digital X-ray
  • Dual-energy X-ray Absorptiometry (DEXA)
  • Animal Irradiator
  • Cell Irradiator
  • Animal Irradiator (Image-Guided)

Contact

Waisman Brain Imaging Core

Mission

The Waisman Brain Imaging Core is central to the integration of behavioral and biological research at the Waisman Center IDDRC.  The core provides access to state-of-the-art neuroimaging instrumentation, tools for image analysis, and expert advice on the design, acquisition, and analysis for imaging studies. Examination of alterations in brain structure, function, and neurochemistry is critical to our understanding of the causal pathways from environmental or genetic processes and for the development of preventive or ameliorative interventions.

Services

  • 3T Human MRI – Structural, Functional, DTI, Advanced Imaging Technologies, Simulator
  • Human PET/CT –  January 2019 installation, radiotracer production for 11C and 18F tracers
  • NHP mPET – Longitudinal studies of animal models of human disease
  • Human fNIRS – Functional brain mapping with near infrared spectroscopy
  • Psychophysiology – Recording suite, EMG, skin conductance, heart rate in shielded environment
  • Computing Resources – 142TB of storage, 288 computing cores, 250 computers
  • Expert Advice – Data acquisition, study conduct best-practices, analysis

Equipment

  • GE X750 3.0T MRI scanner
  • Siemens Biograph Horizon PET/CT scanner
  • Siemens ECAT Exact HR+ PET scanner
  • Siemens P4 & Focus220 microPET preclinical scanners
  • National Electrostatics Corporation 9SDH-2 electrostatic tandem accelerator
  • NIRx Medical Technologies portable NIRScout FNIRS system
  • Centralized computing: 142TB network storage, desktop & software support
  • Psychophysiology Suite: shielded subject room, video monitoring, BIOPAC MP160 system
  • MRI simulator

Contact

֍  Utilizes iLab Management System